BioAdvanced All-in-One Rose and Flower Care granules is convenient, easy-to-use and takes the guesswork out of application. It is 3-systemic products in one: fertilizer, insect control and disease control. All-In-One Rose and Flower Care requires no spraying! Apply the granules to the base of the plant, sprinkle evenly under the branches, work into top 1 to 2 inches of soil, then water in. Systemic formula cannot be washed off by rain. Use it to protect up to 32 roses, shrubs, and flowers from Aphids, Caterpillars, Black Spot, Powdery Mildew, Rust, Southern Blight and other listed insects and diseases for up to 6 weeks. Begin using in the Spring when plants are actively growing. Reapply every 6 weeks for a total of 3 applications per year. People and pets can reenter area after product has been watered in and allowed to dry. BioAdvanced. Get More From The Blue Bottle.