BioAdvanced All-in-One Rose and Flower Care concentrate is convenient, easy-to-use and takes the guesswork out of application. It is 3-systemic products in one: fertilizer, insect control and disease control. Just mix with water in a bucket and pour as close to plant base as possible, then water in. All-In-One Rose and Flower Care's systemic formula cannot be washed off by rain. Use it to protect your roses and flowers from Aphids, Black Spot, Powdery Mildew, Rust, Southern Blight and other listed insects and diseases for up to 6 weeks. 64 oz. concentrate treats up to 32 roses and other shrubs, or 400 sq. ft. of flowerbed. Begin using in the spring when plants are actively growing. Reapply every 6 weeks for a total of 3 applications per year. People and pets may reenter treated areas after drench solution has dried. BioAdvanced. Get More From The Blue Bottle.