BioAdvanced All-in-One Rose and Flower Plant Care protects your roses and other plants from damage done by Aphids, Japanese Beetles and other listed pests. It also works to kill and control listed diseases such as Black Spot, Leaf Spot, and Powdery Mildew. All-In-One Rose and Flower Plant Care provides 3-way action: kills existing pests, forms protective barrier on outside of plant and is absorbed into the plant regardless of weather conditions. It kills listed insects on contact, controls plant mites, and controls listed diseases, and keeps on protecting for up to 2 weeks. Use when listed insects, plant mites, or diseases first appear. This 1 gal. bottle treats up to 16 rose bushes, or about 436 sq. ft. To treat existing diseases, apply at least 3 times, every 14 days apart beginning at the first sign of disease. To prevent diseases, apply at least 3 times, every 14 days apart during the growing season, starting when new leaves first appear. Treat pests and diseases early in the season before they multiply. People and pets may enter the area after the spray has dried. Spraying your rose bushes, ground covers, vines, ornamentals, shrubs and trees has never been easier. BioAdvanced. Get More From The Blue Bottle.