Our exclusive formula provides long-lasting control against listed insects, diseases and mites in one easy step. BioAdvanced 3-In-1 Insect, Disease and Mite Control 32 oz. Concentrate makes up to 12 gal. of spray. Apply with pump-style tank sprayer, dial-style hose-end sprayer, or concentrate plus water-hose-end sprayer according to label directions on trees, shrubs, rose bushes and flower plants in the early morning or late evening. It is an exclusive formula that provides long-lasting control against listed insects, cures and prevents listed diseases and controls spider mites in one easy step. Its systemic rainproof protection lasts up to 30 days, so growing trees, shrubs, flowers and roses has never been easier. To treat existing diseases, apply at least 3 times, every 14 days apart beginning at the first sign of disease. To prevent diseases, apply at least 3 times, every 14 days apart during the growing season, starting when new leaves first appear. People and pets may enter the area after the spray has dried. BioAdvanced. Get More From The Blue Bottle.